Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Encephalopathy
ADR ID BADD_A01462
ADR Hierarchy
17      Nervous system disorders
17.13      Encephalopathies
17.13.02      Encephalopathies NEC
17.13.02.001      Encephalopathy
Description A disorder characterized by a pathologic process involving the brain. [CTCAE] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM. [MeSH]
MedDRA Code 10014625
MeSH ID D001927
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Encephalopathy | Encephalopathy acute | Encephalopathy chronic | Encephalopathy NOS | Encephalopathy, unspecified | Influenza encephalopathy | Brain Diseases | Brain Disease | Brain Disorders | Brain Disorder | Intracranial CNS Disorders | Central Nervous System Intracranial Disorders | CNS Disorders, Intracranial | CNS Disorder, Intracranial | Intracranial CNS Disorder | Encephalon Diseases | Encephalon Disease | Intracranial Central Nervous System Disorders | Central Nervous System Disorders, Intracranial | Encephalopathies
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Dihydropyrimidine dehydrogenase [NADP(+)]Q12882T75890
Gamma-aminobutyric acid receptor subunit beta-1P15431Not Available
TransketolaseP29401T67754
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00330Cabozantinib0.001332%
BADD_D00349Capecitabine--
BADD_D00356Carbamazepine0.005893%
BADD_D00364Carboplatin0.001332%
BADD_D00367Carfilzomib0.001332%
BADD_D00371Carmustine--
BADD_D00386Cefepime0.002768%
BADD_D00390Cefotaxime--
BADD_D00399Ceftazidime--
BADD_D00400Ceftazidime pentahydrate--
BADD_D00405Ceftriaxone0.102129%
BADD_D00463Cidofovir--
BADD_D00464Cidofovir dihydrate--
BADD_D00474Cisplatin0.001066%
BADD_D00475Citalopram--
BADD_D00480Clarithromycin--
BADD_D00488Clobazam0.001505%
BADD_D00499Clomipramine--
BADD_D00500Clomipramine hydrochloride--
BADD_D00501Clonazepam0.000259%
BADD_D00504Clopidogrel--
BADD_D00511Clozapine--
BADD_D00535Crizotinib--
BADD_D00545Cyclobenzaprine0.000066%
BADD_D00549Cyclophosphamide--
BADD_D00551Cyclosporine0.001817%
BADD_D00554Cyproterone--
BADD_D00555Cyproterone acetate--
BADD_D00556Cysteamine--
BADD_D00557Cysteamine bitartrate--
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